Resource from here
- Immune checkpoint inhibitors-> usually unleash immune response against cancer and has been used in cancer treatments (immunotherapy)
- Many colorectal cancer does not respond to immunotherapy
- (Why?) -> This article might explain, more annotations on this blog post
- Liver metastases are very resistant to immune checkpoint blockade
- Lack dendritic cells -> can’t activate cytotoxic T lymphocytes -> can’t activate killing of cancer cells
- Potential outcomes and legacy
- Benefits of orthotopic tumor models
- More research should be done on dendritic cells’ immune functions
- Unless there already are some?
- New therapies for resistant colorectal cancer -> clinical trial using immune checkpoint inhibitor + dendritic growth factor Flt3L
When the team augmented the number of dendritic cells within liver metastases…. the treatment led to an increase in cytotoxic T lymphocytes within the tumors and caused the tumors to become sensitive to immune checkpoint inhibitors.
https://news.harvard.edu/gazette/story/2021/10/new-way-to-overcome-colorectal-cancers-resistance-to-immune-response/
